Ukugqithisa ngokweqile kwandisa umngcipheko wokugcinwa kwamanzi kunye ne-hyponatremia.Ukulawulwa kwe-hyponatremia kuyahluka kumntu nomntu.Kwizigulane ezine-non-symptomatic hyponatremia, i-desmopressin kufuneka iyekwe kwaye ukuthathwa kolwelo kuthintelwe.Kwizigulane ezine-symptomatic hyponatremia, kuyacetyiswa ukuba ungeze isotonic okanye i-hypertonic sodium chloride kwi-drip.Kwiimeko zokugcinwa kwamanzi kakhulu (i-cramps kunye nokulahlekelwa kwengqondo), unyango nge-furosemide kufuneka longezwe.
Izigulane ezinonxano oluqhelekileyo okanye lwengqondo;i-angina pectoris engazinzanga;ukuphazamiseka kwemetabolism ukungoneli kwentliziyo;uhlobo IIB vascular hemophilia.Ingqwalasela ekhethekileyo kufuneka ihlawulwe kumngcipheko wokugcinwa kwamanzi.Ukuthathwa kolwelo kufuneka kuncitshiswe kube kuncinci kangangoko kwaye ubunzima kufuneka bujongwe rhoqo.Ukuba kukho ukunyuka kancinci kubunzima bomzimba kunye ne-sodium yegazi iyancipha ngaphantsi kwe-130 mmol / L okanye i-plasma osmolality iwela ngaphantsi kwe-270 mosm / kg, ukuthathwa kwamanzi kufuneka kuncitshiswe kakhulu kwaye i-desmopressin iyekwe.Sebenzisa ngokuqaphela kwizigulane ezincinci okanye ezikhulileyo;kwizigulane ezinezinye iziphazamiso ezifuna unyango lwe-diuretic ngokungalingani kwamanzi kunye / okanye ukunyibilika;nakwizigulane ezisemngciphekweni wokunyuka koxinzelelo lwe-intracranial.Imiba ye-coagulation kunye nexesha lokopha kufuneka lilinganiswe ngaphambi kokusetyenziswa kweli chiza;I-plasma concentrations ye-VIII: C kunye ne-VWF: AG yonyuka kakhulu emva kokulawulwa, kodwa akunakwenzeka ukuseka ulungelelwaniso phakathi kwamanqanaba e-plasma yale miba kunye nexesha lokopha ngaphambi nangemva kokulawulwa.Ngoko ke ukuba kuyenzeka, isiphumo se-desmopressin kwixesha lokopha kumntu ngamnye kufuneka simiselwe ngokomfuniselo.
Ukumiselwa kwexesha lokopha kufuneka kubekwe emgangathweni kangangoko kunokwenzeka, umzekelo, ngendlela yeSimplate II.Iziphumo zokuKhulelwa nokuncancisa Uvavanyo lokuzala kwiimpuku kunye nemivundla olulawulwa kumaxesha angaphezulu kwekhulu kwidosi yomntu lubonise ukuba i-desmopressin ayilonakalisi i-embryo.Omnye umphandi uye wachaza iimeko ezintathu zokungalungi kwiintsana ezizalwa ngabasetyhini abakhulelweyo abasebenzisa i-desmopressin ngexesha lokukhulelwa, kodwa ezinye iingxelo zeemeko ezingaphezu kwe-120 ziye zabonisa ukuba iintsana ezizalwa ngabasetyhini abasebenzisa i-desmopressin ngexesha lokukhulelwa zaziqhelekileyo.
Ukongeza, uphononongo olubhalwe kakuhle alubonakalisi ukwanda kwezinga lokuzalwa kakubi kwiintsana ezingama-29 ezizalwe ngabasetyhini abakhulelweyo abasebenzisa i-desmopressin ngexesha lonke lokukhulelwa.Uhlalutyo lobisi lwebele olusuka kwabasetyhini abongikazi abanyangwa ngeedosi eziphezulu (300ug intranasal) lubonise ukuba isixa se-desmopressin esigqithiselwa kusana sasingaphantsi kakhulu kwisixa esifunekayo ukuchaphazela i-diuresis kunye ne-hemostasis.
Amalungiselelo: Iziyobisi ezichasayo zinokunyusa impendulo yesigulana kwi-desmopressin ngaphandle kokwandisa ixesha lesenzo.Ezinye izinto ezaziwa ngokukhupha iihomoni ze-antidiuretic, ezifana ne-tricyclic antidepressants, i-chlorpromazine, kunye ne-carbamazepine, zenza i-antidiuretic effect.Yandisa umngcipheko wokugcinwa kwamanzi.
Ixesha lokuposa: Jan-23-2024