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Ubonelelo lomvelisi iCilengitide 98% umgubo omhlophe CAS NO.188968-51-6 Umfanekiso obonakalayo
  • Ukubonelela ngomvelisi iCilengitide 98% umgubo omhlophe CAS NO.188968-51-6
  • Ukubonelela ngomvelisi iCilengitide 98% umgubo omhlophe CAS NO.188968-51-6
  • Ukubonelela ngomvelisi iCilengitide 98% umgubo omhlophe CAS NO.188968-51-6

Ukubonelela ngomvelisi iCilengitide 98% umgubo omhlophe CAS NO.188968-51-6

Cilengitide CAS NO: 188968-51-6
I-Cilengitide yi-peptide ye-cyclic pentapeptide ekhuphisana ne-arginine-glycine-aspartate (RGD) yokulandelelana kwepeptide.Ilawula ukubophelela kwe-integrin-ligand.I-Cilengitide inqanda ngokufanelekileyo nangokufanelekileyo i-alpha v beta 3 ye-beta kunye ne-alpha v 5 integrin edibeneyo kunye neeprotheni ze-matrix, ezifana ne-Vitronectin, i-Fibronectin, i-Fibrinogen, i-vonWillebrandFactor, i-Osteopontin, kunye nabanye.I-10μMCingiChemicalbooktide inqanda ngokupheleleyo ukunamathela kwe-BAE, BME kunye neeseli zeHUVE kwiVitronectin kunye neFibronectin.I-Cilengitide isebenza kwi-vitro kwiiseli ze-BAE ezenziwe kwangaphambili nge-FGF-2 (okanye i-VEGF-A) ye-collagen ene-dimensional emithathu kunye ne-blood fibrin gel ukuvimbela i-angiogenesis kunye ne-IC50 ye-15 kunye ne-8μM, kunye ne-4 kunye ne-3μM, ngokulandelanayo.I-Cilengitide inqanda ukwanda kweeseli, ibangela i-endothelial cell apoptosis, kwaye ibangele ulwahlulo lweseli endothelial.


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Igama lemveliso Cilengitide
CAS 188968-51-6
ifomula yemolekyuli C27H40N8O7
ubunzima bemolekyuli 588.66
ukuxinana 1.41±0.1 g/cm3(Kuxelwe kwangaphambili)
ukunyibilika ≥29.43 mg / mL kwi-DMSO;≥22.56 mg / mL kwi-H2O
I-acidity coefficient (pKa) 4.01±0.10(Kuqikelelwe)
uhlengahlengiso (1)
uhlengahlengiso (1)
uhlengahlengiso (2)

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