Imathiriyeli esulungekileyo ekrwada iThymosin Beta 4 TB500/ TB-500 iqhekeza cas 885340-08-9

I-TB500 i-molecule yokwenziwa kwindawo esebenzayo ye-thymosin beta 4. I-TB500 ikhuthaza ukuhlukana kweeseli ze-endothelial, i-angiogenesis kwi-dermis tissue, ukufuduka kweeseli, i-collagen deposition kunye nokunciphisa ukuvuvukala.Chaza i-angiogenesis (ANG), iprotheni ye-14,124 Da ehambelana ne-angiogenesis ekuqhubekeni kwe-tumor.Ifihliwe ngamaseli e-tumor, ezi-inducers ezisebenzayo zokwenziwa kwemithambo yegazi emitsha.
Iimpawu zesakhiwo Acharya et al.uzimisele ukwakhiwa kwekristale ye-antigens yabantu kwi-2.4 0 A. Isakhiwo esipheleleyo sinemigobe emithathu enezintso ezikhumbuza i-RNaseA.Iziko lomsebenzi we-RNA lysis (i-His-13, i-His-114 kunye ne-Lys-40) kunye ne-hypothetical receptor binding sites, imisebenzi emibini ephambili ye-biological participatory yahlukile kwi-Rnase A 5. Umbindi we-molekyuli uquka iperi ye-P- izakhiwo ezinokuphazamiseka kwe-anti-parallel, ezenza i-topology engundoqo, kunye nesiseko esishiyekileyo se-Ser-72 kunye ne-Gly-99 kwii-vertices.Isakhiwo esikhulu esine-flaky sigqitywe ngamatyathanga amabini ongezelelweyo ngapha nangapha kula matyathanga aphakathi (intsalela ye-41-47; 111-116).Kukho i-3 helix H1, intsalela ye-3-14, i-H2, i-22-33 eshiyekileyo kunye ne-H3, kunye ne-49-58 eseleyo.